Negative regulation of cell adhesion molecule production

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell adhesion molecule production pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTSE1-DT, COL15A1, and RNU6-810P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell adhesion molecule production activity versus GTSE1-DT in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GTSE1-DT →	+0.245	+0.666	.001	.008	3	3
GBM	COL15A1 →	+0.727	+0.617	.001	<.001	3	3
CCRCC	RNU6-810P →	+0.416	+0.440	.001	.008	3	2
CCRCC	VDAC1P4 →	-0.200	-0.479	.006	.002	3	2
CCRCC	MIR122HG →	+0.383	+0.636	.001	.001	3	2
BRCA	PRR32 →	-0.069	-0.068	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060354 vs GTSE1-DT — LUAD

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