Glycerophospholipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glycerophospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHJ1, NSA2P3, and SLC39A4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid biosynthetic process activity versus PLEKHJ1 in CCRCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PLEKHJ1 →	-0.278	-0.214	.002	.006	3	3
COAD	NSA2P3 →	-0.749	-0.775	.001	.002	3	2
CCRCC	SLC39A4 →	-0.966	-0.237	<.001	.002	3	2
CCRCC	CHD1 →	+0.484	+0.267	<.001	.001	3	2
CCRCC	SLFN5 →	+0.612	+0.304	.005	.001	3	2
CCRCC	ZBTB8OSP2 →	+0.816	+0.296	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046474 vs PLEKHJ1 — CCRCC

Explore this scatter interactively →