Glycerophospholipid biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Glycerophospholipid biosynthetic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 207 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Glycerophospholipid biosynthetic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BLCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, UVM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.436	0.207	<.001	133	view →
UVM	DFS	Median	III,IV	0.269	0.701	<.001	48	view →
LGG	OS	Tertile	All	0.302	0.537	<.001	48	view →
BLCA	OS	Quartile	All	0.809	0.657	.002	38	view →
BRCA	DFS	Tertile	III,IV	0.655	0.417	.006	33	view →
DLBC	DFS	Median	III,IV	0.074	0.984	.003	26	view →
ACC	DFS	Quartile	All	0.357	0.758	.009	22	view →
SCLC	DFS	Quartile	All	0.881	0.541	.005	22	view →
ESCA	OS	Tertile	III,IV	0.636	0.306	.007	12	view →
READ	DFS	Quartile	IV	0.262	0.889	.017	8	view →
PRAD	OS	Quartile	All	0.982	1.000	.007	6	view →
LUSC	DFS	Quartile	III,IV	0.398	1.000	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0046474–HNSC (DFS)

Open the HNSC breakdown →