Negative regulation of B cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD11, CAMK4, and GPR52, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell differentiation activity versus KCTD11 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KCTD11 →	+0.675	+0.799	<.001	.002	3	4
GBM	CAMK4 →	-0.803	-0.287	<.001	.009	3	3
LUAD	GPR52 →	-0.217	-0.485	.005	.004	3	3
OV	NPM1P40 →	-0.778	-0.855	<.001	<.001	3	3
OV	BCL6 →	+0.753	+0.546	.002	.004	1	5
CCRCC	LRP1 →	+0.585	+0.638	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045578 vs KCTD11 — LSCC

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