Q-omics provides the consensus-scored NPM1P40 profile across patient tissues and cancer cell-line models. NPM1P40 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, NPM1P40 is differentially expressed in 7, with the highest sampling consensus in COAD. Additionally, NPM1P40 RNA expression shows 6,808 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight THCA, COAD, and UVM as cancer lineages where NPM1P40 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NPM1P40 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NPM1P40 survival associations across molecular data types. NPM1P40 RNA expression shows survival associations in the most cancer types (27). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NPM1P40 RNA expression–survival associations across cancer types. High NPM1P40 expression shows unfavorable associations in KICH, ESCA, KIRC, LIHC and CHOL, but favorable associations in THCA. The THCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify THCA as the clearest survival context for NPM1P40 RNA expression.
This table summarizes NPM1P40 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for NPM1P40. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NPM1P40 shows lower tumor expression in THCA and higher tumor expression in COAD, KIRC, LUAD, HNSC and CHOL. The COAD box plot shows higher NPM1P40 RNA expression in tumor versus normal tissue (log2 FC = +0.176, t-test p < 0.001).
This table shows molecular features associated with NPM1P40 in patient tissues and cancer cell lines. In patient samples, NPM1P40 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
