Mitotic DNA integrity checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic DNA integrity checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, PIF1, and CDT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA integrity checkpoint signaling activity versus MCM4 in BRCA (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MCM4 →	+0.881	+1.001	<.001	<.001	3	6
BRCA	PIF1 →	+0.815	+0.616	<.001	<.001	3	6
GBM	CDT1 →	+0.964	+0.852	.001	.008	3	6
BRCA	MCM5 →	+0.449	+0.472	.001	.003	3	5
LSCC	LMNB1 →	+0.732	+0.600	.002	.005	3	5
LSCC	TOP2A →	+1.123	+0.594	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044774 vs MCM4 — BRCA

Explore this scatter interactively →