Mitotic DNA integrity checkpoint signaling

Across TCGA pan-cancer cohorts, RNA activity of the Mitotic DNA integrity checkpoint signaling pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 87 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Mitotic DNA integrity checkpoint signaling pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRC, MESO, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.513	0.721	<.001	166	view →
MESO	OS	Median	All	0.386	0.638	<.001	144	view →
ACC	DFS	Median	All	0.351	0.707	<.001	118	view →
UVM	DFS	Quartile	All	0.227	0.950	<.001	89	view →
LIHC	DFS	Median	All	0.454	0.610	<.001	79	view →
LGG	OS	Median	All	0.679	0.930	<.001	54	view →
KIRP	OS	Median	All	0.551	0.797	<.001	51	view →
READ	OS	Tertile	II,III,IV	1.000	0.322	<.001	38	view →
UCEC	DFS	Median	All	0.795	0.875	.005	32	view →
SARC	OS	Tertile	All	0.409	0.819	<.001	31	view →
UCS	OS	Median	IV	0.844	0.234	.005	24	view →
SCLC	OS	Median	All	0.589	0.371	.020	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0044774–KIRC (DFS)

Open the KIRC breakdown →