Angiotensin-activated signaling pathway

Across TCGA patient cohorts, RNA activity of the Angiotensin-activated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_S67, FCGBP, and PPIP5K1_S1073, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Angiotensin-activated signaling pathway activity versus NCL_S67 in GBM (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCL_S67 →	-0.818	-0.093	<.001	<.001	3	6
LUAD	FCGBP →	+1.139	+0.115	<.001	<.001	3	6
COAD	PPIP5K1_S1073 →	+0.730	+0.060	.001	.004	3	5
UCEC	PRKCA →	+0.395	+0.076	.001	.008	3	5
UCEC	CNRIP1 →	+0.450	+0.077	.002	<.001	3	5
LSCC	ATL1_S10 →	+0.451	+0.053	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038166 vs NCL_S67 — GBM

Explore this scatter interactively →