Angiotensin-activated signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Angiotensin-activated signaling pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Angiotensin-activated signaling pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and READ, show the opposite pattern, with higher activity associated with better survival.

BRCA, LGG, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.877	0.737	.012	40	view →
LGG	DFS	Tertile	All	0.643	0.790	<.001	39	view →
READ	OS	Median	II,III,IV	0.889	0.508	.004	30	view →
KICH	OS	Median	III,IV	0.369	0.866	.006	27	view →
HNSC	OS	Quartile	IV	0.566	0.334	.014	25	view →
UVM	DFS	Quartile	All	0.277	0.859	.001	22	view →
BLCA	DFS	Quartile	III,IV	0.313	0.612	.004	17	view →
SKCM	OS	Median	IV	0.867	0.244	.006	17	view →
STAD	DFS	Tertile	III,IV	0.412	0.766	.001	13	view →
MESO	OS	Tertile	IV	0.241	0.680	.035	12	view →
LIHC	OS	Quartile	III,IV	1.000	0.750	.022	12	view →
KIRP	OS	Median	II,III,IV	0.319	0.697	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0038166–BRCA (DFS)

Open the BRCA breakdown →