Angiotensin-activated signaling pathway

Across TCGA patient cohorts, RNA activity of the Angiotensin-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN2B, MITF, and MEF2C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Angiotensin-activated signaling pathway activity versus SCN2B in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCN2B →	+0.564	+0.279	<.001	<.001	3	6
BRCA	MITF →	+0.895	+0.235	<.001	<.001	3	6
HNSC	MEF2C →	+0.655	+0.143	.001	<.001	3	6
HNSC	RIPOR2 →	+0.872	+0.262	<.001	<.001	3	6
HNSC	SELPLG →	+0.656	+0.132	.001	.001	3	5
BRCA	CNRIP1 →	+0.986	+0.254	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038166 vs SCN2B — BRCA

Explore this scatter interactively →