Angiotensin-activated signaling pathway

Across TCGA cell cohorts, RNA activity of the Angiotensin-activated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROCK2, AGT, and ROCK1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ROCK2 grouped by Angiotensin-activated signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ROCK2 →	-0.291	-1.509	<.001	<.001	3	10
CNS	AGT →	-0.312	-1.250	<.001	<.001	3	9
LUNG_NSCLC_LUAD	ROCK1 →	-0.182	-0.956	.002	.004	2	8
SOFT_TISSUE	DNAJA4 →	+0.388	+1.655	.004	.001	3	5
KIDNEY	RHOU →	-0.290	-1.752	<.001	<.001	3	5
LARGE_INTESTINE	RARG →	-0.212	-1.036	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ROCK2 by Angiotensin-activated signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →