Ionotropic glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Ionotropic glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP1, C14orf28, and ADCY9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFAIP1 grouped by Ionotropic glutamate receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TNFAIP1 →	-0.773	-0.643	.001	.008	3	4
BREAST	C14orf28 →	-0.472	-0.819	.001	.003	3	4
SKIN	ADCY9 →	-0.690	-1.063	.003	<.001	3	4
SKIN	ZNF555 →	-0.331	-0.796	.003	.001	2	5
SKIN	KLHDC1 →	-0.369	-0.689	.006	.007	3	4
SOFT_TISSUE	APOBEC3C →	-2.574	-0.821	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFAIP1 by Ionotropic glutamate receptor signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →