Ionotropic glutamate receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Ionotropic glutamate receptor signaling pathway pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Ionotropic glutamate receptor signaling pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and UCEC, show the opposite pattern, with higher activity associated with better survival.

LGG, UCEC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.878	0.745	<.001	46	view →
UCEC	OS	Median	All	0.841	0.573	.002	38	view →
KIRC	DFS	Median	All	0.710	0.518	.008	23	view →
LIHC	OS	Quartile	All	0.871	0.665	.001	22	view →
LUSC	OS	Median	III,IV	0.902	0.294	.005	18	view →
DLBC	DFS	Median	II,III,IV	0.567	0.971	.016	16	view →
CESC	DFS	Tertile	All	0.882	0.782	.014	12	view →
KIRP	OS	Quartile	III,IV	1.000	0.689	.017	12	view →
SKCM	OS	Tertile	IV	0.230	0.787	.012	11	view →
LUAD	OS	Quartile	All	0.569	0.745	.031	10	view →
THCA	DFS	Median	All	0.868	0.942	.004	10	view →
COAD	DFS	Quartile	IV	0.779	0.418	.015	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0035235–LGG (OS)

Open the LGG breakdown →