Positive regulation of fatty acid beta-oxidation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fatty acid beta-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1A, TCF25, and STRAP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid beta-oxidation activity versus CPT1A in LUNG_SCLC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CPT1A →	+2.481	+1.748	.005	.001	3	9
BLOOD_Myeloma	TCF25 →	-1.083	-1.867	.001	.001	3	4
OESOPHAGUS	STRAP →	-0.669	-1.553	.004	.005	3	4
URINARY_TRACT	UBE2I →	-0.696	-1.865	.004	<.001	2	5
LARGE_INTESTINE	HNRNPD →	-0.772	-1.483	.003	<.001	3	4
LARGE_INTESTINE	EXO1 →	-0.850	-1.486	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032000 vs CPT1A — LUNG_SCLC

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