Striated muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Striated muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the STAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNPO2, ZDHHC17, and NPTN-IT1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle cell apoptotic process activity versus SYNPO2 in STAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SYNPO2 →	+2.061	+0.039	<.001	<.001	3	32
UVM	ZDHHC17 →	+1.010	+0.025	<.001	<.001	3	30
SARC	NPTN-IT1 →	+0.845	+0.033	<.001	<.001	3	30
THYM	NFAT5 →	+1.934	+0.043	<.001	<.001	3	29
DLBC	RAPGEF2 →	+1.293	+0.053	<.001	.001	3	29
THYM	SASH1 →	+1.263	+0.036	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010658 vs SYNPO2 — STAD

Explore this scatter interactively →