Q-omics provides the consensus-scored NPTN-IT1 profile across patient tissues and cancer cell-line models. NPTN-IT1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, NPTN-IT1 is differentially expressed in 9, with the highest sampling consensus in BRCA. Additionally, NPTN-IT1 RNA expression shows 19,800 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LUSC, BRCA, and THYM as cancer lineages where NPTN-IT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NPTN-IT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NPTN-IT1 survival associations across molecular data types. NPTN-IT1 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NPTN-IT1 RNA expression–survival associations across cancer types. High NPTN-IT1 expression shows unfavorable associations in LUSC, THCA, UVM, CESC and OV, but favorable associations in ACC. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for NPTN-IT1 RNA expression.
This table summarizes NPTN-IT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for NPTN-IT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NPTN-IT1 shows lower tumor expression in BRCA and THCA and higher tumor expression in KIRC, LIHC, CHOL and KICH. The BRCA box plot shows higher NPTN-IT1 RNA expression in normal versus tumor tissue (log2 FC = −0.465, t-test p < 0.001).
This table shows molecular features associated with NPTN-IT1 in patient tissues and cancer cell lines. In patient samples, NPTN-IT1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
