NPTN-IT1

Across TCGA pan-cancer cohorts, NPTN-IT1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NPTN-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where NPTN-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types NPTN-IT1 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

BRCA, KIRC, and THCA are the cancer types where NPTN-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPTN-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.465	<.001	6	view →
KIRC	All	All	+0.241	<.001	6	view →
THCA	Female	All	−0.454	<.001	5	view →
LIHC	All	All	+0.110	.001	5	view →
CHOL	All	II,III,IV	+0.985	.001	4	view →
KICH	All	II,III,IV	+0.486	.003	4	view →
READ	All	III,IV	−0.535	.002	3	view →
UCEC	All	All	−0.699	<.001	2	view →
LUSC	All	II,III,IV	−0.372	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NPTN-IT1–BRCA

Open the BRCA breakdown →