NPTN-IT1

Across TCGA pan-cancer cohorts, NPTN-IT1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NPTN-IT1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NPTN-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPTN-IT1 expression acts as an unfavorable survival marker, although some lineages such as ACC and BRCA show a favorable association.

LUSC, ACC, and THCA are the cancer types where NPTN-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	III,IV	0.215	0.951	<.001	41	view →
ACC	OS	Median	II,III,IV	0.926	0.317	<.001	36	view →
THCA	DFS	Median	II,III,IV	0.404	0.876	.004	34	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	32	view →
CESC	DFS	Quartile	All	0.700	0.878	.006	28	view →
OV	OS	Median	III,IV	0.792	0.873	.005	22	view →
BRCA	DFS	Median	III,IV	0.595	0.404	.013	21	view →
COAD	DFS	Tertile	III,IV	0.183	0.572	.013	15	view →
MESO	DFS	Tertile	All	0.296	0.448	.036	15	view →
PCPG	OS	Median	All	0.934	1.000	.016	13	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	12	view →
READ	OS	Quartile	II,III,IV	0.902	0.343	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NPTN-IT1–LUSC (DFS)

Open the LUSC breakdown →