Oxaloacetate metabolic process

Across TCGA patient cohorts, RNA activity of the Oxaloacetate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCK2, STRBP, and TOMM70, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxaloacetate metabolic process activity versus PCK2 in HNSC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PCK2 →	+0.614	+0.104	<.001	<.001	3	8
HNSC	STRBP →	+0.458	+0.076	<.001	.004	3	5
GBM	TOMM70 →	+0.307	+0.046	<.001	.001	3	5
PDAC	SRRT_S26 →	+0.375	+0.048	.001	<.001	3	5
PDAC	TOP2A_S1377 →	+0.976	+0.046	.002	.007	3	5
LSCC	MTMR9 →	-0.213	-0.060	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006107 vs PCK2 — HNSC

Explore this scatter interactively →