Oxaloacetate metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Oxaloacetate metabolic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in kidney chromophobe (KICH), where higher Oxaloacetate metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and LIHC, show the opposite pattern, with higher activity associated with better survival.

KICH, ACC, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.673	0.974	<.001	109	view →
ACC	DFS	Tertile	II,III,IV	0.155	0.718	<.001	86	view →
BLCA	OS	Tertile	II,III,IV	0.573	0.349	.002	44	view →
LIHC	DFS	Median	All	0.530	0.369	<.001	32	view →
UCS	DFS	Median	III,IV	0.261	0.559	.014	20	view →
SARC	DFS	Tertile	All	0.530	0.694	.006	17	view →
LUSC	DFS	Tertile	All	0.487	0.324	.012	17	view →
PRAD	OS	Tertile	All	0.941	1.000	.012	14	view →
THCA	DFS	Median	IV	0.459	0.874	.004	14	view →
THYM	DFS	Tertile	II,III,IV	0.784	0.967	.009	13	view →
CHOL	DFS	Quartile	All	0.798	0.124	.017	13	view →
MESO	DFS	Median	III,IV	0.292	0.510	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0006107–KICH (DFS)

Open the KICH breakdown →