Mannose metabolic process

Across TCGA cell cohorts, RNA activity of the Mannose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H1, TPST1, and CNKSR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P3H1 grouped by Mannose metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	P3H1 →	-1.412	-1.679	.003	<.001	3	5
KIDNEY	TPST1 →	-0.905	-1.331	<.001	.001	3	5
SOFT_TISSUE	CNKSR3 →	-1.994	-1.901	<.001	<.001	3	4
LIVER	FAAH →	+3.090	+1.885	<.001	.003	3	4
BREAST	CLDN3 →	+2.694	+1.101	.005	<.001	3	4
KIDNEY	SNAI2 →	-2.441	-1.538	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P3H1 by Mannose metabolic process activity — KIDNEY

Explore this box plot interactively →