Response to ischemia

Across TCGA patient cohorts, RNA activity of the Response to ischemia pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CADM4, GBP3, and SLCO2B1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ischemia activity versus CADM4 in CCRCC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CADM4 →	-0.546	-0.301	.004	.003	3	4
LUAD	GBP3 →	+0.716	+0.156	.003	.004	3	4
LUAD	SLCO2B1 →	+0.377	+0.107	.001	.001	3	4
LUAD	SQSTM1 →	+0.730	+0.168	<.001	<.001	3	4
LUAD	TLR3 →	+0.470	+0.120	<.001	<.001	3	4
LUAD	CIITA →	+0.591	+0.156	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002931 vs CADM4 — CCRCC

Explore this scatter interactively →