Response to ischemia

Across TCGA cell cohorts, RNA activity of the Response to ischemia pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPEB4, NUP85, and IL13RA1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ischemia activity versus CPEB4 in BONE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CPEB4 →	+1.663	+0.101	<.001	<.001	3	9
BLOOD_Lymphoma	NUP85 →	-0.638	-0.038	.001	.007	3	9
BONE	IL13RA1 →	+2.680	+0.092	<.001	<.001	3	9
BONE	SLC30A1 →	+1.437	+0.110	<.001	<.001	3	9
BLOOD_Leukemia	WDR45 →	+0.659	+0.052	.004	.006	3	8
LIVER	SRSF2 →	-0.607	-0.060	.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002931 vs CPEB4 — BONE

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