zinc finger protein 408Genealiases: EVR6 · PRDM17 · RP72
Q-omics provides the consensus-scored ZNF408 profile across patient tissues and cancer cell-line models. ZNF408 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, ZNF408 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, ZNF408 RNA expression shows 17,859 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight LIHC, KIRC, and ACC as cancer lineages where ZNF408 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF408 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF408 survival associations across molecular data types. ZNF408 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (5) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF408 RNA expression–survival associations across cancer types. High ZNF408 expression shows unfavorable associations in LIHC, KICH, ACC and MESO, but favorable associations in UCEC and THYM. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for ZNF408 RNA expression.
This table summarizes ZNF408 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 2. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for ZNF408. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF408 shows higher tumor expression in KIRC, KIRP, HNSC, COAD, LIHC and STAD. The KIRC box plot shows higher ZNF408 RNA expression in tumor versus normal tissue (log2 FC = +0.739, t-test p < 0.001).
This table shows molecular features associated with ZNF408 in patient tissues and cancer cell lines. In patient samples, ZNF408 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF408 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Lymphoma.
