ZNF408

Across TCGA patient cohorts, ZNF408 mutation is significantly associated with the RNA expression of many other genes, with 776 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF408-associated genes across cancer lineages are RN7SL248P, MIR8082, and RN7SL321P. Each is linked with ZNF408 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF408-to-partner and partner-to-ZNF408 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by ZNF408-low versus ZNF408-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF408→partner) and Y-score (partner→ZNF408) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.074	+3.474	<.001	<.001	3	2
UCEC	MIR8082 →	+0.274	+2.059	.001	.005	3	2
CESC	RN7SL321P →	+0.230	+4.760	<.001	.003	3	2
COAD	OSBPL9P5 →	+0.169	+5.412	<.001	.001	3	2
STAD	RN7SL870P →	+0.202	+2.876	<.001	.006	3	2
STAD	MIR379 →	+0.176	+3.537	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 776 associations by consensus.

RN7SL248P by ZNF408 expression — UCEC

Explore this box plot interactively →