ZNF408

Across TCGA patient cohorts, ZNF408 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,103 significant associations in total. LGG shows the largest number of these associations.

The most reproducible ZNF408-associated GO terms across cancer lineages are tRNA thio-modification, Obsolete positive regulation of histone deacetylation, and Free ubiquitin chain polymerization. Each is linked with ZNF408 in more than 21 cancer types. Because this analysis shows association rather than direction, both ZNF408-to-partner and partner-to-ZNF408 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA thio-modification grouped by ZNF408-low versus ZNF408-high in READ.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF408→partner) and Y-score (partner→ZNF408) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	tRNA thio-modification →	+0.052	+0.367	<.001	<.001	3	22
SCLC	Obsolete positive regulation of histone deacetylation →	+0.081	+0.390	.003	.004	1	22
TGCT	Free ubiquitin chain polymerization →	+0.054	+0.426	<.001	<.001	3	19
SCLC	Obsolete regulation of histone deacetylation →	+0.083	+0.372	.002	.005	1	21
ACC	Base-excision repair, gap-filling →	+0.041	+0.753	.001	.001	3	19
SCLC	Nucleolar chromatin organization →	+0.132	+0.482	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,103 associations by consensus.

tRNA thio-modification by ZNF408 expression — READ

Explore this box plot interactively →