ZNF408

Across TCGA cell cohorts, ZNF408 mutation is significantly associated with the mutation status of many other genes, with 1,939 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF408-associated genes across cancer lineages are POLRMT, CCDC157, and BRWD1. Each is linked with ZNF408 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF408-to-partner and partner-to-ZNF408 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLRMT grouped by ZNF408-low versus ZNF408-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF408→partner) and Y-score (partner→ZNF408) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLRMT →	+2.215	+4.169	<.001	<.001	1	3
CNS	CCDC157 →	+5.044	+5.614	.003	.003	1	3
UPPER_AERODIGESTIVE_TRACT	BRWD1 →	+2.954	+4.247	.006	.006	1	3
CNS	MMRN1 →	+4.459	+5.277	.005	.005	1	3
BLOOD_Leukemia	LRP4 →	+2.845	+3.209	.003	.003	1	3
UPPER_AERODIGESTIVE_TRACT	LGI3 →	+4.954	+4.392	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,939 associations by consensus.

POLRMT by ZNF408 expression — LARGE_INTESTINE

Explore this box plot interactively →