ZNF408

Across TCGA patient cohorts, ZNF408 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF408-associated genes across cancer lineages are PDK1_pS241, YB-1, and Caspase-7-cleavedD198. Each is linked with ZNF408 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF408-to-partner and partner-to-ZNF408 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by ZNF408-low versus ZNF408-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF408→partner) and Y-score (partner→ZNF408) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDK1_pS241 →	-0.337	-3.169	<.001	.018	3	2
SKCM	YB-1 →	+0.372	+3.321	<.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.640	+2.189	.010	.034	3	2
UCEC	MSH6 →	-0.398	-3.169	.004	.018	3	1
UCEC	Notch1 →	+0.172	+2.331	.004	.019	3	1
UCEC	PDCD4 →	-0.605	-2.222	.002	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PDK1_pS241 by ZNF408 expression — SKCM

Explore this box plot interactively →