ZNF114

Across TCGA cell cohorts, ZNF114 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF114-associated genes across cancer lineages are GSG1L2, C16orf90, and OR4A47. Each is linked with ZNF114 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF114-to-partner and partner-to-ZNF114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by ZNF114-low versus ZNF114-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF114→partner) and Y-score (partner→ZNF114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	2
LUNG_SCLC	C16orf90 →	+0.066	+4.044	<.001	.009	3	1
LUNG_SCLC	OR4A47 →	+0.035	+4.817	<.001	.001	3	1
LUNG_SCLC	KRTAP9-1 →	+0.193	+4.044	<.001	.009	3	1
BLOOD_Leukemia	RGS7 →	+0.359	+3.769	<.001	.008	3	1
BLOOD_Leukemia	PIGY →	+2.098	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GSG1L2 by ZNF114 expression — BLOOD_Leukemia

Explore this box plot interactively →