ZNF114

Across TCGA pan-cancer cohorts, ZNF114 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZNF114 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF114 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF114 expression acts as an unfavorable survival marker, although some lineages such as LAML and THYM show a favorable association.

HNSC, MESO, and SKCM are the cancer types where ZNF114 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.647	0.742	.001	99	view →
MESO	OS	Quartile	All	0.334	0.714	<.001	63	view →
SKCM	OS	Tertile	All	0.291	0.423	<.001	60	view →
ACC	DFS	Median	All	0.429	0.735	<.001	57	view →
UCEC	DFS	Quartile	All	0.557	0.800	<.001	44	view →
PAAD	DFS	Median	All	0.269	0.440	.001	35	view →
STAD	OS	Quartile	II,III,IV	0.270	0.678	.004	34	view →
KIRC	DFS	Median	II,III,IV	0.435	0.616	.001	34	view →
LUSC	OS	Tertile	III,IV	0.574	0.773	.007	27	view →
LAML	DFS	Tertile	All	0.530	0.264	.003	26	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.460	.010	17	view →
THCA	DFS	Tertile	IV	0.664	0.945	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZNF114–HNSC (DFS)

Open the HNSC breakdown →