ZNF114

Across TCGA pan-cancer cohorts, ZNF114 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF114’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF114 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF114 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

HNSC, BLCA, and UCEC are the cancer types where ZNF114 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF114 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.248	<.001	12	view →
BLCA	All	III,IV	+1.139	<.001	10	view →
UCEC	All	II,III,IV	+2.008	.002	6	view →
LUAD	Male	III,IV	+1.641	.002	6	view →
LUSC	Male	II,III,IV	+1.352	<.001	6	view →
KIRC	All	All	+0.594	.001	6	view →
COAD	Male	All	+0.442	<.001	6	view →
LIHC	Female	All	+0.099	<.001	6	view →
STAD	Male	IV	+1.185	.002	5	view →
KIRP	Female	All	−0.437	.001	3	view →
KICH	Male	All	−0.308	.018	2	view →
PRAD	All	All	−0.269	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF114–HNSC

Open the HNSC breakdown →