Q-omics provides the consensus-scored WDR31 profile across patient tissues and cancer cell-line models. WDR31 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, WDR31 is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, WDR31 RNA expression shows 20,385 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, KICH, and THYM as cancer lineages where WDR31 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WDR31 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WDR31 survival associations across molecular data types. WDR31 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WDR31 RNA expression–survival associations across cancer types. High WDR31 expression shows unfavorable associations in BLCA, but favorable associations in KIRC, UCEC, UVM, KIRP and COAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for WDR31 RNA expression.
This table summarizes WDR31 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 2. The strongest signals are observed in KICH for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for WDR31. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WDR31 shows lower tumor expression in KICH, THCA, KIRC and HNSC and higher tumor expression in COAD and CHOL. The KICH box plot shows higher WDR31 RNA expression in normal versus tumor tissue (log2 FC = −2.311, t-test p < 0.001).
This table shows molecular features associated with WDR31 in patient tissues and cancer cell lines. In patient samples, WDR31 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, WDR31 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and BLOOD_Leukemia.
