UQCRHL

Across TCGA patient cohorts, UQCRHL mutation is significantly associated with the RNA expression of many other genes, with 765 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRHL-associated genes across cancer lineages are ARHGAP42P3, ICE2P1, and OR7E21P. Each is linked with UQCRHL in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRHL-to-partner and partner-to-UQCRHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP42P3 grouped by UQCRHL-low versus UQCRHL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRHL→partner) and Y-score (partner→UQCRHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP42P3 →	+0.033	+3.379	<.001	.001	3	2
UCEC	ICE2P1 →	+0.068	+2.638	.002	.003	3	2
SKCM	OR7E21P →	+0.063	+4.628	<.001	.004	3	1
SKCM	MRPS21P8 →	+0.187	+4.970	<.001	.005	3	1
SKCM	DNM1P28 →	+0.144	+5.809	<.001	<.001	3	1
SKCM	MTATP6P24 →	+0.102	+5.809	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 765 associations by consensus.

ARHGAP42P3 by UQCRHL expression — UCEC

Explore this box plot interactively →