UQCRHL

Across TCGA pan-cancer cohorts, UQCRHL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UQCRHL’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where UQCRHL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UQCRHL is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

LIHC, LUSC, and KIRC are the cancer types where UQCRHL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UQCRHL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.704	<.001	9	view →
LUSC	Female	All	+0.956	<.001	8	view →
KIRC	Male	II,III,IV	−0.708	<.001	8	view →
COAD	Female	II,III,IV	+0.771	<.001	6	view →
LUAD	Male	All	+0.615	<.001	6	view →
BLCA	All	All	+0.414	.010	6	view →
HNSC	All	All	+0.192	.008	4	view →
CHOL	Male	All	+1.116	<.001	3	view →
KICH	Female	All	−0.522	.007	3	view →
STAD	Female	All	+0.571	.049	2	view →
UCEC	All	All	+0.510	.008	2	view →
THCA	Male	All	−0.267	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UQCRHL–LIHC

Open the LIHC breakdown →