UCMA

Across TCGA patient cohorts, UCMA mutation is significantly associated with the RNA expression of many other genes, with 1,516 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCMA-associated genes across cancer lineages are PPP1R26P4, PPIAP56, and RCN1P1. Each is linked with UCMA in more than 2 cancer types. Because this analysis shows association rather than direction, both UCMA-to-partner and partner-to-UCMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R26P4 grouped by UCMA-low versus UCMA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCMA→partner) and Y-score (partner→UCMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP1R26P4 →	+0.013	+5.356	<.001	<.001	3	3
SKCM	PPIAP56 →	+0.128	+4.402	<.001	.002	3	2
UCEC	RCN1P1 →	+0.094	+2.068	.008	.004	3	2
COAD	HNRNPA1P58 →	+0.158	+3.697	.005	.004	3	2
COAD	RNU6-628P →	+0.467	+3.622	<.001	.002	3	2
COAD	RPS12P5 →	+0.400	+3.734	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,516 associations by consensus.

PPP1R26P4 by UCMA expression — SKCM

Explore this box plot interactively →