UCMA

Across TCGA pan-cancer cohorts, UCMA RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of UCMA’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UCMA RNA is repressed in tumor relative to normal tissue. In most cancer types UCMA is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA and KIRP are the cancer types where UCMA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UCMA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.023	.037	2	view →
KIRP	Male	All	−0.034	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

UCMA–THCA

Open the THCA breakdown →