UCMA

Across TCGA pan-cancer cohorts, UCMA RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated UCMA data layer compared with 3 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher UCMA RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated UCMA expression acts as an unfavorable survival marker, although some lineages such as MESO and STAD show a favorable association.

MESO, STAD, and THCA are the cancer types where UCMA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.496	0.218	.005	48	view →
STAD	DFS	Median	III,IV	0.688	0.493	.011	45	view →
THCA	OS	Tertile	III,IV	0.819	0.993	<.001	42	view →
BLCA	DFS	Tertile	All	0.173	0.383	.008	30	view →
THYM	OS	Tertile	III,IV	0.212	0.953	.009	27	view →
LGG	DFS	Quartile	All	0.651	0.766	.004	23	view →
PCPG	DFS	Tertile	All	0.544	0.850	.006	18	view →
ACC	DFS	Median	IV	0.540	0.108	.011	9	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.038	9	view →
SKCM	OS	Tertile	III,IV	0.538	0.721	.032	6	view →
GBM	OS	Tertile	All	0.310	0.448	.026	6	view →
ESCA	OS	Tertile	All	0.442	0.609	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

UCMA–MESO (DFS)

Open the MESO breakdown →