TRPM3

Across TCGA cell cohorts, TRPM3 mutation is significantly associated with the mutation status of many other genes, with 5,811 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM3-associated genes across cancer lineages are LRP1, MVP, and ABCB1. Each is linked with TRPM3 in more than 5 cancer types. Because this analysis shows association rather than direction, both TRPM3-to-partner and partner-to-TRPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRP1 grouped by TRPM3-low versus TRPM3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM3→partner) and Y-score (partner→TRPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LRP1 →	+3.672	+4.614	.002	.002	1	6
SKIN	MVP →	+4.133	+3.450	<.001	<.001	1	6
LARGE_INTESTINE	ABCB1 →	+2.998	+2.386	<.001	<.001	1	6
SOFT_TISSUE	TMEM131 →	+3.437	+3.437	.006	.006	1	6
BLOOD_Lymphoma	GRIK2 →	+3.969	+3.969	.002	.002	1	6
UPPER_AERODIGESTIVE_TRACT	ADCY8 →	+4.954	+4.392	.008	.008	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,811 associations by consensus.

LRP1 by TRPM3 expression — PANCREAS

Explore this box plot interactively →