TRPM3

Across TCGA pan-cancer cohorts, TRPM3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRPM3 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TRPM3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRPM3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, KIRP, and BLCA are the cancer types where TRPM3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.756	0.510	<.001	152	view →
KIRP	OS	Quartile	All	0.984	0.839	<.001	101	view →
BLCA	OS	Median	IV	0.132	0.338	.004	45	view →
LIHC	OS	Tertile	III,IV	0.629	0.183	.003	32	view →
HNSC	OS	Median	All	0.433	0.694	<.001	29	view →
DLBC	DFS	Median	IV	0.245	0.877	.006	18	view →
CESC	OS	Quartile	IV	0.332	0.619	.008	16	view →
GBM	DFS	Tertile	All	0.163	0.288	.020	15	view →
ACC	OS	Median	All	0.467	0.756	.010	14	view →
SKCM	DFS	Median	All	0.245	0.162	.005	12	view →
CHOL	DFS	Tertile	All	0.841	0.127	.006	12	view →
ESCA	OS	Quartile	IV	0.167	0.738	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRPM3–KIRC (OS)

Open the KIRC breakdown →