TRPM3

Across TCGA pan-cancer cohorts, TRPM3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRPM3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TRPM3 RNA is repressed in tumor relative to normal tissue. In most cancer types TRPM3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRP are the cancer types where TRPM3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPM3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.248	<.001	11	view →
THCA	Male	IV	−0.710	<.001	10	view →
KIRP	All	III,IV	−1.496	<.001	8	view →
KIRC	Male	III,IV	−1.038	<.001	8	view →
BRCA	Female	All	−0.285	<.001	6	view →
UCEC	All	IV	−0.280	.002	6	view →
LIHC	All	II,III,IV	+0.180	.010	4	view →
LUAD	Female	II,III,IV	−0.074	<.001	3	view →
PRAD	All	All	−0.259	<.001	2	view →
BLCA	Male	IV	−0.210	.009	2	view →
LUSC	Male	III,IV	−0.122	.001	2	view →
STAD	Male	III,IV	−0.043	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRPM3–KICH

Open the KICH breakdown →