TOP2A

Across TCGA cell cohorts, TOP2A mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOP2A-associated genes across cancer lineages are GNPDA2, KRTAP16-1, and PROP1. Each is linked with TOP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP2A-to-partner and partner-to-TOP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPDA2 grouped by TOP2A-low versus TOP2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP2A→partner) and Y-score (partner→TOP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNPDA2 →	+0.779	+3.364	.002	.002	3	2
BLOOD_Leukemia	KRTAP16-1 →	+0.245	+2.895	<.001	.006	3	2
LARGE_INTESTINE	PROP1 →	+0.020	+2.317	<.001	.004	3	2
PANCREAS	OR52N5 →	+0.013	+5.614	<.001	.002	3	1
LARGE_INTESTINE	ANKRD54 →	+0.511	+3.237	.002	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.699	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

GNPDA2 by TOP2A expression — LARGE_INTESTINE

Explore this box plot interactively →