TOP2A

Across TCGA pan-cancer cohorts, TOP2A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TOP2A data layer compared with 9 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TOP2A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOP2A expression acts as an unfavorable survival marker, although some lineages such as READ and COAD show a favorable association.

KIRP, MESO, and ACC are the cancer types where TOP2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.761	0.940	<.001	164	view →
MESO	OS	Median	All	0.360	0.715	<.001	141	view →
ACC	DFS	Median	All	0.234	0.642	<.001	137	view →
LIHC	DFS	Median	All	0.447	0.634	<.001	93	view →
KICH	OS	Tertile	III,IV	0.253	1.000	.001	88	view →
PAAD	OS	Median	All	0.265	0.546	<.001	78	view →
KIRC	DFS	Quartile	All	0.462	0.706	<.001	73	view →
READ	DFS	Quartile	All	0.774	0.282	.004	64	view →
UVM	DFS	Tertile	II,III,IV	0.284	0.840	<.001	60	view →
LGG	OS	Median	All	0.718	0.909	<.001	54	view →
LUAD	OS	Median	All	0.759	0.861	<.001	47	view →
COAD	OS	Quartile	II,III,IV	0.985	0.775	.002	35	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TOP2A–KIRP (DFS)

Open the KIRP breakdown →