TOP2A

Across TCGA pan-cancer cohorts, TOP2A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TOP2A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TOP2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TOP2A is over-expressed in tumor.

HNSC, BLCA, and LUAD are the cancer types where TOP2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOP2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+2.294	<.001	12	view →
BLCA	Male	IV	+5.127	<.001	11	view →
LUAD	Male	III,IV	+4.511	<.001	11	view →
KIRP	All	IV	+4.420	<.001	11	view →
KIRC	Male	All	+2.284	<.001	11	view →
THCA	All	III,IV	+1.381	<.001	10	view →
LUSC	Female	All	+4.869	<.001	9	view →
STAD	Female	All	+3.334	<.001	9	view →
LIHC	Female	II,III,IV	+3.055	<.001	9	view →
COAD	Male	III,IV	+1.765	<.001	9	view →
UCEC	All	III,IV	+4.649	<.001	6	view →
BRCA	All	II,III,IV	+3.430	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TOP2A–HNSC

Open the HNSC breakdown →