TOE1

Across TCGA patient cohorts, TOE1 mutation is significantly associated with the RNA expression of many other genes, with 2,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOE1-associated genes across cancer lineages are MIR3181, SDR42E1P4, and RN7SL248P. Each is linked with TOE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOE1-to-partner and partner-to-TOE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3181 grouped by TOE1-low versus TOE1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOE1→partner) and Y-score (partner→TOE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR3181 →	+0.613	+5.268	<.001	.006	3	2
SKCM	SDR42E1P4 →	+0.277	+7.219	<.001	<.001	3	2
UCEC	RN7SL248P →	+0.050	+2.847	<.001	.008	3	2
COAD	RNU6-1322P →	+1.473	+5.017	<.001	.009	3	2
COAD	RNU6-906P →	+2.233	+5.283	<.001	.006	3	2
SKCM	RSU1P3 →	+0.070	+5.159	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,777 associations by consensus.

MIR3181 by TOE1 expression — LIHC

Explore this box plot interactively →