TOE1

Across TCGA pan-cancer cohorts, TOE1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TOE1 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TOE1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TOE1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and CHOL show a favorable association.

LIHC, KICH, and ACC are the cancer types where TOE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.427	0.594	<.001	81	view →
KICH	DFS	Median	III,IV	0.308	0.942	.001	77	view →
ACC	DFS	Tertile	All	0.207	0.799	<.001	76	view →
LGG	DFS	Median	All	0.644	0.834	<.001	54	view →
SCLC	DFS	Quartile	All	0.525	0.205	.003	43	view →
CHOL	DFS	Quartile	All	1.000	0.159	.004	28	view →
KIRP	DFS	Median	III,IV	0.347	0.796	<.001	27	view →
KIRC	DFS	Median	All	0.866	0.718	.001	24	view →
COAD	DFS	Median	II,III,IV	0.579	0.342	.005	19	view →
HNSC	OS	Quartile	All	0.831	0.735	.012	15	view →
READ	DFS	Quartile	All	0.851	0.574	.016	13	view →
CESC	DFS	Median	IV	0.096	0.424	.039	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TOE1–LIHC (OS)

Open the LIHC breakdown →