TOE1

Across TCGA pan-cancer cohorts, TOE1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TOE1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TOE1 RNA is repressed in tumor relative to normal tissue. In most cancer types TOE1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where TOE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.350	<.001	10	view →
LIHC	Female	II,III,IV	+0.773	<.001	8	view →
THCA	All	IV	−0.767	<.001	8	view →
HNSC	All	All	+0.368	<.001	8	view →
STAD	Male	II,III,IV	+0.980	<.001	6	view →
KIRP	All	All	−0.465	<.001	5	view →
COAD	Female	All	+0.379	.004	4	view →
CHOL	Male	All	+1.461	<.001	3	view →
PRAD	All	All	−0.296	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TOE1–KICH

Open the KICH breakdown →