TMEM179

Across TCGA patient cohorts, TMEM179 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM179-associated genes across cancer lineages are RNU6-918P, MIR4716, and CLUHP8. Each is linked with TMEM179 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM179-to-partner and partner-to-TMEM179 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-918P grouped by TMEM179-low versus TMEM179-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM179→partner) and Y-score (partner→TMEM179) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-918P →	+0.500	+5.224	<.001	.007	3	2
SKCM	MIR4716 →	+0.490	+5.771	<.001	.003	3	2
UCEC	CLUHP8 →	+0.176	+3.302	.001	.009	3	2
BRCA	MIR3118-3 →	+0.558	+8.471	<.001	.005	3	1
BRCA	H3P46 →	+0.193	+7.731	<.001	.009	3	1
HNSC	DRD5P2 →	+0.025	+5.578	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

RNU6-918P by TMEM179 expression — SKCM

Explore this box plot interactively →