TMEM179

Across TCGA pan-cancer cohorts, TMEM179 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM179’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM179 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM179 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where TMEM179 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM179 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.803	<.001	11	view →
KIRC	Male	All	+1.036	<.001	9	view →
KICH	All	II,III,IV	−0.136	.001	7	view →
READ	All	All	−0.806	.001	6	view →
KIRP	All	III,IV	+1.420	.001	5	view →
STAD	Female	III,IV	−0.725	.004	5	view →
LUSC	All	All	+0.792	<.001	4	view →
BRCA	Female	II,III,IV	+0.324	<.001	4	view →
THCA	Female	All	+0.196	<.001	4	view →
CHOL	All	All	+0.682	.010	2	view →
UCEC	All	IV	+0.450	.030	2	view →
LUAD	All	All	+0.362	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM179–COAD

Open the COAD breakdown →