Q-omics provides the consensus-scored SUSD4 profile across patient tissues and cancer cell-line models. SUSD4 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SUSD4 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, SUSD4 RNA expression shows 16,210 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRC, and TGCT as cancer lineages where SUSD4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SUSD4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SUSD4 survival associations across molecular data types. SUSD4 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SUSD4 RNA expression–survival associations across cancer types. High SUSD4 expression shows unfavorable associations in KIRC, KIRP, UVM and UCEC, but favorable associations in LUSC and LUAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SUSD4 RNA expression.
This table summarizes SUSD4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for SUSD4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SUSD4 shows lower tumor expression in KIRC, KICH, KIRP and HNSC and higher tumor expression in THCA and LUSC. The KIRC box plot shows higher SUSD4 RNA expression in normal versus tumor tissue (log2 FC = −3.656, t-test p < 0.001).
This table shows molecular features associated with SUSD4 in patient tissues and cancer cell lines. In patient samples, SUSD4 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, SUSD4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
