SUSD4

Across TCGA cell cohorts, SUSD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,838 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SUSD4-associated GO terms across cancer lineages are Negative regulation of complement activation, alternative pathway, Negative regulation of complement activation, classical pathway, and Regulation of complement activation, classical pathway. Each is linked with SUSD4 in more than 18 cancer types. Because this analysis shows association rather than direction, both SUSD4-to-partner and partner-to-SUSD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of complement activation, alternative pathway grouped by SUSD4-low versus SUSD4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SUSD4→partner) and Y-score (partner→SUSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of complement activation, alternative pathway →	+1.943	+3.061	<.001	<.001	3	19
BONE	Negative regulation of complement activation, classical pathway →	-0.399	-1.894	<.001	<.001	3	15
BONE	Regulation of complement activation, classical pathway →	-0.409	-1.894	<.001	<.001	3	13
BONE	Negative regulation of humoral immune response mediated by circulating immunoglobulin →	-0.407	-1.903	<.001	<.001	3	11
BONE	Regulation of humoral immune response mediated by circulating immunoglobulin →	-0.416	-1.903	<.001	<.001	3	10
OVARY	Regulation of cell cycle G1/S phase transition →	+0.051	+1.664	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,838 associations by consensus.

Negative regulation of complement activation, alternative pathway by SUSD4 expression — BREAST

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